Acute middle ear mastoiditis is usually caused by a bacterial infection and can be treated with anti-infective medication as prescribed by the doctor. Chronic mastoiditis of the middle ear will have the symptoms of pus and hearing loss, and doctors will recommend surgery. The treatment for mastoiditis needs to be different from one condition to another, and the best treatment is the one that suits your condition. 1. Acute middle ear mastoiditis: first of all, you should choose a sufficient amount of antibiotics, generally can consider levofloxacin, amoxicillin and cefixime, the use of drugs please follow the doctor’s instructions. If there is pus in the mastoid as well as in the middle ear, or if it causes intracranial or extracranial complications, the treatment of pus drainage can be chosen. 2. Chronic middle ear mastoiditis: For simple mastoid effusion, radical mastoidectomy can be chosen. However, if there is destruction of the middle ear structure or combined with cholesteatoma, tympanoplasty can be chosen to rebuild the basic functional structure under the premise of removing the lesion. The treatment of middle ear mastoiditis requires standardized medication and treatment after a systematic examination by a specialist to clarify the diagnosis and condition.