Theoretically, stem cell transplantation has a certain therapeutic effect on coronary heart disease, but at present, the relevant treatment means are still in the research and experimental stage, in which the mechanism, safety, therapeutic effect and long-term performance are not very clear, so it can’t be applied to the clinic yet. Stem cell transplantation, as the name suggests, is the transplantation of differentiated stem cells to the site of myocardial ischemia or myocardial infarction in patients with coronary artery disease. Stem cells with differentiation ability can be differentiated into vascular endothelial cells, smooth muscle cells, and cardiomyocytes, so that the blood supply of ischemic or infarcted myocardium can be restored, and the newborn myocardium can replenish the necrotic myocardium and enhance the heart contraction function. At this stage, it is recommended that patients with coronary artery disease should standardize their treatment under the guidance of their doctors and choose the appropriate treatment method.