Painful bladder stones can be treated with general therapy, medication, and surgical stone removal to relieve pain. However, the specific efficacy varies from person to person. 1. General treatment: Drink more water and urinate more often in daily life. 2. Drug treatment: if accompanied by infection, anti-infection drugs can be used for treatment. Commonly used are levofloxacin and so on. When the pain is obvious, you can take ibuprofen and other pain relief treatment. The use of specific drugs should be under the guidance of the doctor. 3. Surgery for stone removal: it is the main treatment measure. If the stone is small, <5mm, transurethral cystoscopy can be applied directly. If the stone is large and difficult to be removed directly, endoscopic minimally invasive lithotripsy can be used to remove the stone. If you have bladder stones, it is recommended that you consult a doctor in a timely manner and choose an appropriate treatment plan under the guidance of your doctor.