The treatments for recurrence of lung cancer with multiple metastases five months after surgery include chemotherapy, radiotherapy, targeted therapy and immunotherapy. Recurrence of lung cancer with multiple metastases five months after surgery indicates that the patient has entered the advanced stage and has more metastatic foci, therefore, it is difficult to take surgical treatment, and most of the patients need to take systemic combined with local, simultaneous radiotherapy and chemotherapy to inhibit the growth and invasion of the tumor, stabilize the condition of the patient and prolong the life span of the patient. If genetic testing reveals that patients have EGFR gene mutations, they can also choose targeted drugs such as gefitinib, erlotinib, afatinib, ositinib, etc.; or use nivolizumab, pabolizumab, etc. to carry out immunotherapy combined with chemotherapy treatment.