Normal lymph nodes in the liver and spleen are usually not enlarged. When enlargement occurs, inflammation of the liver and spleen, tumor or metastasis of malignant tumors are most often considered. 1. Hepatic lymph nodes usually refer to the lymph nodes at the liver portal, which are not enlarged under normal conditions. However, when there are pathogenic microorganisms such as bacteria, virus and other infections at the liver portal, or when there are tumor diseases such as liver cancer, cholangiocarcinoma, gallbladder cancer, or liver metastasis of malignant tumors such as gastric cancer, liver lymph nodes will be enlarged. 2. Spleen itself is a lymphatic tissue, which will not be enlarged under normal condition. When splenomegaly occurs, it is mostly due to the inflammatory reaction caused by the presence of viral, bacterial, microbial and other infections in the patient. Patients with cirrhosis, chronic heart failure and other diseases may also have splenomegaly due to impaired blood return. 3. Certain hematologic diseases, such as chronic lymphocytic leukemia, myelodysplastic syndromes, and certain connective tissue diseases, such as systemic lupus erythematosus and dermatomyositis, can also lead to splenomegaly. Therefore, when the patient has enlarged liver and spleen lymph nodes, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment to avoid delaying the condition.