Positive antinuclear antibody suggests that there may be systemic lupus erythematosus, mixed connective tissue disease, etc. It is recommended to consult the Rheumatology and Immunology Department in a timely manner, and make a clear diagnosis under the guidance of the doctor and carry out the appropriate treatment. Antinuclear antibody, or ANA, also known as anti-nucleic acid antigen antibody, is a general term for anti-nucleic acid and nucleoprotein antibody, which is an important marker for autoimmune diseases. Normal people should be negative, and positive antibody suggests that patients may have systemic lupus erythematosus, mixed connective tissue disease, dry syndrome, systemic sclerosis, rheumatoid arthritis, etc. Patients with positive antinuclear antibody should be diagnosed and treated accordingly. Patients with positive antinuclear antibody should further improve other autoantibodies, rheumatoid factor, blood sedimentation, CRP and other auxiliary tests to clarify the diagnosis, and follow the doctor’s instructions to use non-steroidal anti-inflammatory drugs such as celecoxib, glucocorticosteroids such as prednisone acetate tablets, and anti-rheumatic drugs such as methotrexate, leflunomide, and so on. It is recommended that patients with positive antinuclear antibodies go to the Department of Rheumatology and Immunology of regular hospitals to clarify the cause of the disease and follow the doctor’s instructions for treatment.