In the middle of the night two fingertip swelling and pain may be gout or infection caused by the cause of the drug treatment, physical therapy, surgical treatment. 1. gout: mostly because of eating purine more food, and uric acid excretion obstacles, resulting in gout, acute stage can take ice and other physical therapy, oral colchicine or nimesulide dispersible tablets and other medications. 2. Infection: mostly nail groove inflammation or purulent dactylitis, can be applied under the guidance of the doctor anti-inflammatory drugs such as roxithromycin capsules, infrared treatment, if there is pus depending on the circumstances of the incision and drainage, and regular change of medicine. In the middle of the night, the two fingertips swollen and painful need to go to the hospital in time to check a clear diagnosis and further treatment.