Large red and hard bumps on the face can be considered as acne, acute urticaria, soft tissue skin infections, etc. Common treatments include topical medication and internal medication. 1. Acne: People with oily skin are prone to acne when their pores are clogged, which can be manifested as large, red, hard bumps on the face, which can be treated with erythromycin ointment, clindamycin phosphate ointment and other medications under the guidance of a doctor. 2. Acute urticaria: mainly caused by skin contact with allergens, belonging to allergic skin diseases, commonly manifested as long bumps on the face, accompanied by itching, stinging sensation, etc., can be under the guidance of the doctor to take cetirizine, loratadine and other anti-allergy drugs. 3. Skin soft tissue infection: skin cleaning is not in place, bacteria breeding, easy to lead to skin soft tissue infection, will be manifested in the face and red and hard big pimples. At this time, you can take cephalosporin antibiotic treatment under the guidance of the doctor. There are more reasons for the red and hard bumps on the face, and more treatment methods, so it is recommended to go to a professional skin hospital, and through a reasonable way of treatment.