In May this year, our cardiology and surgery departments were the first in China to jointly perform and successfully treat a 37-year-old male patient with perivalvular leak after mitral valve replacement with a transthoracic small-incision puncture catheter seal. The patient had been diagnosed with rheumatic heart disease and underwent aortic valve and mitral valve replacement 17 years ago, and his symptoms had once improved after the surgery, but he had developed dyspnea at night and weakness after activity again in the last six months. On examination, cardiac ultrasound showed that the mitral valve had a mechanical perivalvular leak and caused severe regurgitation of blood in the heart chambers, and the left heart chamber was enlarged. In general, the traditional open-heart replacement or valve repair is highly traumatic and risky, while interventional closure of the perivalvular leak is not easy to perform because of the mechanical aortic valve. After aggressive preoperative preparation, the treatment plan was designed by Director Pan Xin, and the treatment team was composed of cardiothoracic surgery, ultrasound, radiology, and anesthesiology, and a 5 cm incision was made in the cardiac catheterization laboratory at the fifth intercostal space on the left side to separate and expose the cusps. Finally, the position of the blocker was monitored under ultrasound and cardiovascular imaging to observe the effect on the prosthetic valve and the status of blocking before releasing the blocker and successfully blocking the perivalvular leak. The postoperative ultrasound showed that the mitral regurgitation basically disappeared and did not affect the normal opening and closing of the mechanical valve, and the patient was discharged from the hospital 5 days later with significant improvement in the symptoms of cardiac insufficiency. Valvular heart disease still has a high incidence in China, and the vast majority of valve diseases require open-heart surgery for valve replacement at advanced stages of the disease. It is generally accepted that perivalvular leaks occur because of surgical damage to the annulus, especially in combination with valve and annular calcification, resulting in poor healing of the annulus and suture ring. This is followed by inflammation causing suture tears. Perivalvular leakage is one of the common complications after prosthetic heart valve replacement, with an incidence of approximately 2% to 15%. Perivalvular leaks are particularly common in mitral valves. Patients with significant perivalvular regurgitation due to perivalvular leak may present with weakness, dizziness, fever, and a characteristic murmur in the corresponding auscultatory area. Some patients may also present with hemolytic anemia and cardiac insufficiency. These clinical symptoms may appear immediately after the procedure or several years after the procedure. Interventional therapy has the advantages of easy and safe operation, small trauma, no surgical scars, no blood transfusion, short hospital stay, fast postoperative recovery, and low treatment cost, etc. However, this method of treating perivalvular leaks was once considered a restricted area due to the high technical requirements. In 2010, our cardiology department was the first in China to successfully perform transcatheter occlusion of perivalvular leaks after aortic valve mechanical valve replacement and simple mitral valve mechanical valve replacement, and this time, we performed mitral valve perivalvular leak occlusion through a hybrid medical-surgical approach, suggesting that with the effective organization and combination of cardiology, surgery, and ultrasound departments, the comprehensive application of various technologies and materials, and the improvement of interventional techniques, minimally invasive treatment of perivalvular leaks is feasible. The treatment of perivalvular leaks is feasible and will eventually become the treatment of choice for most patients with perivalvular leaks.