Li Zhongzhi proposed: “The reason for sleeplessness is about five: one is qi deficiency, one is yin deficiency, one is phlegm stagnation, one is water suspension, one is stomach disharmony.” Sleeplessness is mostly caused by emotional and moral injuries, poor diet, disorders of labor and rest, and deficiency of the body due to long-term illnesses, which cause disorders of the internal organs, loss of harmony between qi and blood, disorders of yin and yang, and the onset of yang not entering yin. The disease is mainly located in the heart, involving the liver, gallbladder, spleen, stomach and kidney, and there are deficiencies and realities, and more deficiencies than realities. Treatment is based on the principle of tonifying the deficiency and dipping the actual, and adjusting the yin and yang of the internal organs.