It is not a serious disease if UU ≥ 10^4. UU refers to Mycoplasma urealyticum, which tends to invade the human genitourinary system. If the genitourinary system is infected by Mycoplasma urealyticum, the patient will experience symptoms of frequent urination, urinary urgency, and urethral itching. Moreover, the pathogen is mainly transmitted through sexual contact, and 90% of the transmission is through sexual contact, and only 10% is transmitted through contact with contaminated objects. If a patient has Mycoplasma deiuriae ≥10^4, a diagnosis of an STD, i.e., nongonococcal urethritis, is made, and effective treatment is usually with sensitive antibiotics. Commonly used drugs are macrolides, including roxithromycin, azithromycin, and clarithromycin. In addition, proprietary Chinese medicines that clear heat, relieve dampness, and detoxify toxins can be used and can play an adjunctive therapeutic role. Therefore, if UU ≥ 10^4, it suggests suffering from nongonococcal urethritis sexually transmitted disease, but it is not serious and timely treatment can achieve cure.