Ankle sprain swelling day by day needs to be treated according to the severity of the general treatment, drug treatment, surgical treatment and so on. 1. General treatment: If the swelling of ankle sprain is mild at the beginning, you should pay attention to rest and reduce the activities of the ankle. You can apply ice packs within 72 hours and hot packs after 72 hours to promote local blood circulation and edema absorption, and you can also elevate the affected limb to promote blood circulation and reduce swelling. 2. Medication: If the symptoms are more serious, non-steroidal anti-inflammatory drugs such as ibuprofen can be used to reduce the inflammatory reaction and pain symptoms, and drugs such as Mazolin can also be used to reduce swelling. 3. Surgery: If the swelling is very serious, accompanied by severe pain in the sprained area, smell the bone friction sound, etc., and there are abnormal activities locally, ankle fracture must be highly suspected, and after a clear diagnosis, according to the severity of the cast fixation treatment or surgical incision and reduction of the internal fixation treatment. After the ankle sprain, the ankle should be swollen day by day, and then go to the hospital in time, complete the relevant examination, clarify the severity of the injury, and follow the doctor’s instructions for standardized treatment, and do not blindly deal with the treatment and use of medication, in order to avoid delaying the condition.