Alcohol should not be consumed while taking ibuprofen because there are adverse reactions such as bleeding, perforation, and ulcers in the gastrointestinal tract when applying ibuprofen. In case of heavy bleeding, it can lead to shock. Severe perforation can cause acute abdomen and even death by shock. Drinking alcohol, especially high alcohol, has a strong stimulating effect on the gastrointestinal tract. Excessive drinking or drinking a large amount of alcohol in a short period of time can lead to gastritis, ulcers, and even perforation. And the gastrointestinal adverse effects of applying ibuprofen can increase with the increase of alcohol consumption. Therefore, alcoholic beverages should not be consumed or prohibited when applying ibuprofen, regardless of previous gastrointestinal diseases.