Pain in the toes after running may be caused by squeezing the feet during strenuous activities. Especially if the shoes you wear are not loose enough, it can aggravate the pain in your toes. You can rest properly, wear loose shoes or soak your feet in hot water to promote local blood circulation, which can eliminate inflammatory mediators and inflammatory factors as soon as possible. It is also possible that toe pain is caused by onychomycosis, which is particularly likely to occur on the inner or outer side of the big toe. This is mainly due to the growth of the toenail into the tissues on both sides, leading to secondary inflammatory infection of the tissues, redness, swelling, pain, and even pus. If it is caused by onychomycosis, oral antibiotics are required, and an incision to drain the pus or nail extraction is necessary.