Dakinin is the trade name, generic name miconazole nitrate, for antifungal drugs, in the scrotum itching with miconazole nitrate is ineffective may be non-fungal infections caused by the disease, can be considered with eczema, scabies or pubic lice disease and so on. 1. eczema: a variety of internal and external factors can cause epidermal inflammation, in the acute phase can appear papules, papules or blisters, localized intense itching, scratching can have vesicles, there is a plasma oozing. 2. Scabies: caused by contact infection, the scabies mite invades the thin and tender parts of the skin, resulting in the appearance of papules, papules or tunnels, and itching, in the scrotum and other places there will be dark red nodules, that is, the appearance of scabies nodules. 3. Pubic lice disease: pubic lice parasitized in the human body, can cause itching of the pubic hair area, more intense at night, pubic lice move slowly, causing itching of the scrotum area. Scrotal itching after medication is ineffective, it is recommended to consult a doctor in a timely manner to clarify the cause of the disease, targeted treatment.