Herpetiform pustulosis presents as small pustules in the folds of the skin during pregnancy. Herpetigo herpetiformis is a serious skin disease that occurs in pregnant women. The basic skin lesion is a sterile pustule on an erythematous base, often accompanied by severe systemic symptoms, and basically resolves after birth. Small pustules in the skin folds during pregnancy are widespread, clustered pustules within the epidermis on the basis of erythema as seen by the naked eye, and histopathological changes in the skin are seen in the superficial layer of the epidermis as spongy pustules with a large number of neutrophils in the pustular fluid. The formation of spongy pustules is due to the fact that a large number of neutrophils enter upward into the upper part of the spinous layer and accumulate in the spongy reticulum formed by degenerated and thinned epidermal cells. Having a small pustule in the skin folds during pregnancy and not knowing what tests should be done is believed to be something that troubles many people. To help alleviate your worries, the following is an overview of what tests are needed for a small pustule in the skin folds during pregnancy. The case shows the tissue picture of pustular psoriasis, with increased peripheral leukocytes, increased blood sedimentation, hypocalcemia and hypoproteinemia. The disease mostly occurs in the second trimester of pregnancy and gradually remits after delivery, and can recur in another pregnancy. The disease begins rapidly with the sudden appearance of large acute inflammatory erythema in the epidermis in the skin folds (e.g., axillae, lower breasts, groin, umbilicus, flexures of the limbs, external genitalia, etc.), followed by clusters of small, superficial pustules, about the size of a pinpoint to a corn, yellowish white, often arranged in a wreath, semi-ring or map-like pattern, without going through the nodule or blister stage. The lesions alone may also fuse together to form large pustular lakes. The lesions are mildly pruritic, and the pustules dry and crust over a period of time, with new skin lesions appearing around the old lesions. Once the scabs are removed, moist, red, shiny areas are revealed, i.e. wart-like lesions, which eventually heal with epithelial repair and deep pigmentation. In severe cases, the lesions can spread widely throughout the body and are accompanied by chills, flaccid fever, vomiting, diarrhea, delirium and other systemic symptoms, which can involve the buccal mucosa of the mouth, tongue, pharynx, esophageal mucosa is also often involved, forming pustules or erosions, gray plaques, sometimes due to severe painful swallowing and affects eating. The disease is characterized by a chronic course, which can last for several months, with periodic acute attacks, often accompanied by hand and foot convulsions due to hypocalcemia. The diagnosis of the disease is based on the appearance of numerous yellowish-white clusters of pustules arranged in a wreath pattern on the basis of erythema in the skin folds of pregnant women in late pregnancy, accompanied by more severe systemic symptoms and histopathological changes of the skin.