White matter lesions can show no signs in the early stages of the disease, and as the disease progresses cognitive dysfunction, strokes, psychiatric abnormalities, and movement disorders can occur. There is no such thing as 10 signs of leukoencephalopathy. 1. Cognitive dysfunction: It is also commonly known as dementia, including impaired memory, executive function, attention, comprehension and expression. The most significant is the loss of executive function and attention. 2. Stroke: white matter lesions are closely related to stroke. 3. Mental-emotional abnormalities: a state of depression and emotional apathy may occur. 4. Motor and balance disorders: Leukoencephalopathy can lead to gait and balance disorders, which can increase the risk of fall injuries in the elderly, and is the cause of acute injuries and dysfunctions in this group. Symptoms of leukoencephalopathy should be treated promptly to minimize the adverse effects of the disease.