Small blisters on the palms of the hands are very itchy and may be caused by eczema, sweating herpes, ringworm and other diseases. Antihistamines, glucocorticoid drugs, topical skin drying agents, and antifungal internal and external drugs can be given for treatment. 1. Eczema: Eczema is an inflammatory disease of the superficial dermis or epidermis caused by a variety of factors, which may lead to localized pimples and papules with itching. Antihistamines such as loratadine and levocetirizine can be given, which have anti-inflammatory and anti-itch effects. If necessary, with vitamin C, calcium gluconate, can reduce capillary permeability. 2. Sweat herpes: Sweat herpes is a special type of eczema that can occur on the palms of the hands and soles of the feet, resulting in the appearance of small transparent blisters with itching. Topical tretinoin ointment can be used to promote the disappearance of blisters. Topical skin drying agents, such as glycerite lotion, have the effect of drying and itching. 3. Ringworm: Blistering ringworm is caused by fungal infection, resulting in small blisters on the hands with itching. You can use bifonazole cream and miconazole nitrate cream externally, which can promote the disappearance of blisters, and the local stimulation is relatively small. If necessary, oral terbinafine, itraconazole, have inhibited or killed the role of fungi. Small blisters on the hands with itching, consider and skin disease related, you can consult the dermatology department of the hospital, to find the cause, for the cause of the appropriate drug treatment.