HBV-DNA is the deoxyribonucleic acid of the hepatitis B virus, the gene for the hepatitis B virus. HBV-DNA is the deoxyribonucleic acid of the hepatitis B virus, the gene for the hepatitis B virus. It is the most specific, direct and sensitive indicator of hepatitis B virus infection. The higher the HBV-DNA quantification, the more active the virus replication, the more infectious it is, and the more damaging it is to the body. HBV-DNA quantification can be used to determine whether or not you are infected with the hepatitis B virus and the level of viral replication. HBV-DNA quantitative results can also be used to evaluate the efficacy of drug treatment, disease progression and prognosis.