Swelling of the face and legs, and a little nausea, clinically common in the heart, liver, kidney lesions, such as dilated cardiomyopathy, cirrhosis, chronic glomerulonephritis, etc., should be timely compliance with medical advice to receive drug treatment or surgical treatment. 1. Dilated cardiomyopathy: edema is mainly manifested in both lower limbs, which will lead to nausea, fatigue and other symptoms. It can be treated with angiotensin-converting enzyme inhibitors such as captopril and enalapril or diuretics such as hydrochlorothiazide. If necessary, heart transplantation, cardiac resynchronization therapy and other surgeries are taken. 2. Cirrhosis: Nausea, mild diarrhea and other symptoms may appear in the early stage, and edema, bleeding and other symptoms may appear when the condition worsens. Antiviral drugs such as entecavir and liver-protecting drugs such as polyene phosphatidylcholine can be used. If drug treatment is not satisfactory, surgical treatment such as liver transplantation can be chosen. 3. Chronic glomerulonephritis: Edema of the face, lower limbs and abdomen, nausea and vomiting may occur. Pharmacological treatment can be carried out with antihypertensive drugs such as enalapril, lipid regulating drugs such as pravastatin, and antiplatelet drugs such as aspirin. In addition, diseases such as rheumatic heart disease, hypertension, nephrotic syndrome, lupus nephritis, liver cancer and other diseases may also have symptoms such as swelling and nausea. The above medications should be used under the guidance of a doctor, do not blindly use medication on your own. It is recommended that patients consult a doctor in a timely manner to clearly diagnose the cause of the disease, and then carry out targeted treatment to avoid delaying the condition.