In clinical work, many patients with schizophrenia and their families often ask, “How long does this disease require medication?” There is no clear time period. In general, 1. if it is the first onset, older age of onset, obvious positive symptoms, good treatment effect, no family history, etc., medication can be taken for three or five years. 2. if the age of onset is younger, some symptoms remain after regular systemic treatment, family history, withdrawn personality before the disease, few words, etc., medication should be taken for five years or more even if it is the first onset. 3. if it is the second onset. Regardless of the effect, it is generally recommended to take 5-10 years, and if it is the third attack, it is recommended to take medication for a long time.4. Specific to a particular person can take medication under the guidance of a doctor according to the situation. If the symptoms are mainly negative, the duration of medication should be extended. This disease is very easy to relapse, the disease should be treated as early as possible, take medication for a longer period of time, the amount of medication should not be too small, otherwise it will lead to relapse, each relapse of this disease will increase the risk of the next relapse, the more relapses the worse the treatment effect, the sensitivity of more drugs decreases, and the side effects increase. Resulting in the gradual decline of some patients and loss of therapeutic significance.