The antihypertensive drugs in the class of diphenhydramine include nifedipine extended-release tablets, felodipine extended-release tablets, amlodipine benzenesulfonate, etc. There is no one antihypertensive drug that is the best, and the one that is most suitable for you is the best. The drugs of the diphenhydramine class belong to calcium channel blockers, which are the first-line drugs used for hypertension, with vasoprotective effects, mainly through the inhibition of calcium ion in-flow, dilating smooth muscle, relieving excessive vascular tension, diastolic blood vessels, so as to make the blood pressure drop. Common adverse reactions to these drugs include lower extremity edema such as ankle edema, flushing, headache, etc. Headache is transient in most cases. Different people have different levels of sensitivity to the medication, so the effect of the medication will be different, and it is recommended to take the medication under the supervision of a doctor.