Positive p16-KI67 is more serious. p16-KI67 is a nuclear antigen gene for cell proliferation, which is an indicator of cell proliferative activity, and is an important reference value for predicting the transformation of pre-cancerous lesions to cancerous development. A higher degree of positivity indicates more severe cell proliferation. P16 positivity suggests a persistent HPV infection. Both positives require further colposcopy, which is mainly used to screen for cervical lesions, and if both are positive, it indicates a higher probability of cervical cancer. And there is cell proliferation, will it develop into cervical cancer, in this case need to continue to do colposcopy. Colposcopy found that the cervix has lesions, need to do a cervical biopsy, and then do the pathology test, this can determine the severity of cervical lesions. The detection of p16-KI67 requires prompt medical attention.