Cranial defects are one of the common and diverse human congenital anomalies that seriously affect the physical and mental health and quality of life of patients, especially large cranial defects caused by trauma, tumor resection and vascular injury. Currently, the common treatments used for cranial bone injuries are autologous bone and allogeneic bone grafts. However, autologous bone grafts often face the challenges of shape matching and limited sources, and allogeneic bone grafts tend to cause immune rejection. Because of cranial bone repair, many cranial bone repair materials have been introduced, and titanium mesh and PEEK materials are currently used. Although titanium mesh has its advantages, there are still many disadvantages. Titanium mesh manufacturers are disorganized, and because of the high technical requirements of titanium processing, the quality of shaping varies, especially for osteoporotic patients, who often have poor fitting problems. Titanium mesh is influenced by temperature. Due to the inherent deficiency of titanium mesh, it is difficult to perfectly shape the curved parts of the head, such as the forehead and the arch of the eyebrow, and there may be traces of mesh after implantation, which may lead to poor visual effects. PEEK (polyether ether ketone) is a special engineering plastic that looks similar to ordinary plastic, but has many advantages such as high temperature resistance, corrosion resistance, robustness, toughness and fatigue resistance. The PEEK material is known as a better material for skull repair.