Getting up every day with swollen hands may be caused by physiological factors such as too much pressure for too long, drinking too much water before going to bed, or it may be caused by pathological factors such as diseases of the urinary system, cardiovascular system and endocrine system. 1. Physiological factors (1) The hand is pressed for too long: the hand is pressed when sleeping, causing local blood return obstacle, the patient may appear hand swelling, usually after lifting the compression can be gradually recovered. (2) Drinking too much water before going to bed: drinking too much water before going to bed, the body can not be discharged in time, a large amount of water gathered in the hand may appear after getting up the hand swelling, generally by moving the fingers and the whole body can be gradually relieved. 2. Pathological factors (1) Urological diseases: when suffering from nephrotic syndrome, glomerulonephritis and other diseases, the metabolic function of the kidney is impaired, and the metabolism of water and sodium is abnormal, which may result in edema involving the hands, accompanied by bilateral swelling of the eyelids and other parts of the body. (2) Cardiovascular system diseases: when the patient has heart failure, constrictive pericarditis, etc., due to the reduction of cardiac output, venous return restriction, etc., it can cause swelling of the hands or other parts of the body. (3) Endocrine system diseases: such as hypothyroidism, due to thyroid hormone deficiency caused by reduced metabolism, tissues and skin can have mucopolysaccharide accumulation, resulting in the formation of hand swelling. Wake up every day hand swelling can also be seen in other reasons, if the exclusion of physiological factors can not be relieved in a timely manner, it is recommended that patients seek medical attention as soon as possible to clarify the cause of the targeted treatment.