Tenofovir generally refers to tenofovir disoproxil fumarate tablets, which may produce insomnia as a side effect and cause some disruption to sleep. Tenofovir disoproxil fumarate tablets is an antiviral medication that is used primarily to treat HIV-1 (HIV type I) infections as well as chronic hepatitis B. It is usually co-administered with other reverse transcriptase inhibitors. Patients may experience adverse reactions such as diarrhea, abdominal pain, loss of appetite, lactic acidosis, severe hepatomegaly with steatosis, headache, depression, and some patients may also experience insomnia, therefore, tenofovir disoproxil fumarate tablets may have an effect on sleep when used. Patients who are allergic to the drug should be prohibited from using it. Patients should follow the doctor’s instructions to regulate the application, do not overdose, if the adverse symptoms are serious, consult a doctor for appropriate treatment.