For patients with advanced rectal cancer with multiple metastases, if they give up the treatment, the general survival time will not be more than half a year; if they actively receive palliative treatments such as radiotherapy, chemotherapy, etc., the survival time can be prolonged to one to three years. The actual survival time is mainly related to the patient’s general condition, treatment method and psychological state. Advanced rectal cancer with multiple metastases can be controlled by radiotherapy, chemotherapy, immunotherapy and targeted drug therapy to control the development and spread of the tumor, so as to reduce the pain of patients, prolong the survival time and improve the quality of life of patients. Early stage rectal cancer is possible to be cured through surgery, and the 5-year survival rate of mid-stage rectal cancer is about 60%. The key to the survival time of advanced rectal cancer with multiple metastases is whether to follow the doctor’s instruction to standardize the treatment and whether to maintain a healthy lifestyle. It is suggested that patients should keep positive and optimistic mentality, and carry out regular treatment in time.