There are more varieties of ointments that can help to remove calluses, the more commonly used ones are salicylic acid ointment, retinoic acid cream and urea vitamin E cream and so on. Callus is also called callus, is a long-term pressure and friction induced by the thickening of the stratum corneum, in the choice of drugs, mainly to give some with the softening of the keratin, dissolving keratin drugs. 1. Salicylic acid ointment, the main ingredient of which is salicylic acid, has the effect of dissolving keratin and helps to remove the hyperplastic stratum corneum produced by callus. Adverse reactions mainly include localized redness, tingling and other irritation reactions. 2. The main ingredient of retinoic acid cream is retinoic acid, which improves the thickening of the stratum corneum by regulating the abnormal process of epithelial keratinization in the sebaceous glands of hair follicles. Adverse reactions include redness, burning and peeling. 3. Urea Vitamin E cream belongs to a kind of compound preparation, in which vitamin E is a kind of antioxidant drug, urea has the role of dissolving keratin, the two drugs are combined into a compound preparation, has the role of softening the keratin as well as anti-cracking. Adverse effects include localized skin irritation, burning and itching. To ensure the safety of the medication, it should be used under medical supervision.