Since the media reported that Luo Jing, the host of CCTV’s “News Broadcast”, suffered from diffuse large B-cell lymphoma and was admitted to the hospital with many organs infiltrated by lymphoma. This has sparked a concern about lymphoma. In China, the incidence of malignant lymphoma is about 3.5/100,000, and about 11/100,000 in Shanghai, and it is increasing at a rate of 4% per year, with about 45,000 new patients and more than 20,000 deaths per year. Lymphoma occupies the 9th place among the top 10 malignant tumors in men and the 10th place among women. Among young and middle-aged people under 35 years old, the incidence of lymphoma ranks among the top three tumor incidences. However, due to insufficient knowledge of lymphoma, compared with European and American countries, lymphoma patients in China are often diagnosed only when their disease has developed more seriously. So what do our doctors overlook in the face of lymphoma patients? One of the neglects: Progressive lymph node enlargement found during physical examination. About 3/4 of lymphoma patients present with superficial painless progressive lymph node enlargement. By progressive, it means that it grows faster, and often the lymph nodes may be twice the size of the next month, or even more. Painless, which is insidious, is different from inflammatory lymph node enlargement. Neglected No. 2: Young people with persistent fever that resembles a cold are encountered in outpatient clinics. Since lymphoma is mostly seen in young and middle-aged people, 30%-50% of patients with Hodgkin’s lymphoma have systemic symptoms (B symptoms) such as persistent or periodic fever, night sweats, and fatigue of unknown origin, which can easily be mistaken for several consecutive occurrences of the flu. In contrast, about 10% of patients with non-Hodgkin’s lymphoma have B symptoms. Unexplained prolonged low-grade fever or periodic fever should be considered as a possibility of malignant lymphoma, especially if accompanied by itchy skin, excessive sweating, wasting, and the finding of enlarged superficial lymph nodes. Neglected third: lymph node tuberculosis that does not show significant improvement after 1 month of regular treatment or chronic lymphadenitis that does not show significant effect after more than half month of general anti-inflammatory treatment. Fourthly, the pathological diagnosis is still based on cytology, without comprehensive immunohistochemistry, genetics and other comprehensive judgments. Neglected fifth: Lack of understanding of the pathogenetic factors of lymphoma. These factors include: (i) Virus: Long-term and persistent viral infection, suppression of immune function, and activation of oncogenes, leading to malignant proliferation of some lymphocytes. (ii) Immunosuppression: If organ transplant patients require long-term medication to suppress their immune mechanisms, the chance of lymphoma is significantly higher than that of the general population. In particular, the incidence of lymphoma is higher in patients with concomitant viral infections. (iii) Bacterial infections: For example, gastric lymphoma occurs in direct correlation with Helicobacter pylori. (iv) Environmental factors: such as various kinds of radiation, environmental pollution, etc. (v) Other: certain congenital immunodeficiency diseases, such as capillary dilated ataxia, are often complicated by lymphoma, and diseases requiring long-term immunosuppressive drugs, such as systemic lupus erythematosus, rheumatoid and dry syndrome, can also be complicated by malignant lymphoma. (f) Medical long-term application such as phenytoin sodium, ephedrine and anti-tumor drugs can induce lymphoma. Neglected No. 6: Doctors only care about the efficiency of lymphoma chemotherapy and ignore the cure rate. Malignant lymphoma is a disease most likely to be cured, and the efficiency of conventional treatment is generally between 75% and 90%, and any kind of chemotherapy drugs may have certain effect (including hormonal drugs), which may easily give doctors and patients the illusion that the effect is good no matter which hospital or kind of treatment. The consequence is that specialized comprehensive treatment is neglected, resulting in the chronicity of the disease, reducing the disease-free survival rate or losing the chance of cure. Neglect of the seventh: excessive exaggeration of the role of Chinese medicine treatment and food therapy. The biggest limitation of TCM treatment is that it is difficult to treat even two patients with the same prescription, so it is difficult to do a randomized clinical study. In addition, it is much less effective than Western medicine and cannot be used as the main treatment. It can only be used as a remedial treatment in between treatments or as a toxicity reduction treatment during radiotherapy. Food therapy should be considered as an icing on the cake, not a blessing in the snow. It is just like pouring a small bowl of rice into a big vat and then giving a bowl of soup to people for hunger. Ignore the eighth: fine needle puncture to send pathology can be. Fine needle aspiration is difficult to obtain sufficient specimens. It is better to do complete lymph node dissection. However, Demharter et al. concluded that applying a 14G cutting puncture needle to obtain 5 lymph node tissues can accurately diagnose and staging lymphoma. Neglected No. 9: The CHOP protocol is used uniformly in the treatment of lymphoma. The status quo is that in 2008 there were more than 60 pathological types of lymphoma, with different treatments. Among them, the most prevalent diffuse large B-cell lymphoma has as many as 13 types in its latest subclass. The clinical classification into GCB and ABC types by bcl-10, bcl-6 and mum-1 revealed a large difference in response rates to CHOP regimens, with efficiency rates of 74% and 36%, respectively. It can be seen that with the wide application of immunology and molecular biology in clinical practice, the understanding and treatment of malignant lymphoma has jumped to a new level. Neglected No. 10: Long-term complications of lymphoma treatment. For example, in an analysis of causes of death after treatment in 2498 patients with HD, Hoppe RT et al. of Stanford University found a significant decrease in deaths due to HD after 5 years of treatment, and a steep increase in treatment-related deaths, with deaths from other causes far exceeding HD deaths after 15 years.