The main causes of high blood creatinine value are pathologic factors (acute and chronic renal function injury) and physiologic factors (strenuous exercise, etc.). Targeted treatment should be carried out according to the specific causes, such as transfusion of red blood cells, anti-infection, lowering blood pressure, lowering sugar, and renal replacement therapy if necessary. 1. Pathological factors (1) Acute renal impairment: the main causes of acute renal impairment are gastrointestinal bleeding, sepsis, urinary tract obstruction, etc., which need to be relieved under the guidance of doctors, such as transfusion of red blood cells, anti-infection (cefixime), relief of obstruction (extracorporeal shock wave lithotripsy, surgical treatment), etc., so as to achieve the therapeutic purpose of lowering blood creatinine. (2) Chronic renal impairment: If the increase of blood creatinine is caused by chronic renal impairment due to hypertension, diabetes mellitus, chronic nephritis and other diseases, it is recommended to actively control the primary disease, control blood sugar and blood pressure within a reasonable range, so as to slow down the chronic renal impairment, and control creatinine within a reasonable range. If necessary, renal replacement therapy is feasible. 2. Physiological factors: such as strenuous exercise, muscular athletes, eating a lot of meat, etc., can lead to high creatinine, at this time, we need to pay attention to rest, light diet, pay attention to review. The above medication should follow the doctor’s instructions, not unauthorized use, so as not to aggravate the condition. Patients with elevated blood creatinine are recommended to consult regular hospitals and receive standardized treatment under the guidance of physicians.