The main ingredient of antipyretic suppositories is non-steroidal antipyretic and analgesic drugs. Side effects of using antipyretic suppositories can cause skin reaction, dehydration, liver and kidney function impairment, gastrointestinal side effects and so on. 1. Skin reaction: some patients using antipyretic suppositories may have allergic reactions due to the drug components, manifested as skin flushing, red rashes and blisters and other conditions. 2. Dehydration: antipyretic suppositories mainly stimulate the body to sweat to realize the cooling effect, if the patient sweats too much and does not replenish water in time, it may cause dehydration, or even hypotensive shock. 3. Hepatic and renal impairment: antipyretic suppositories have a certain degree of hepatotoxicity, especially after excessive use, there may be elevated aminotransferases, or even bilirubin, resulting in jaundice and so on. In addition, it can also cause damage to the kidneys, hematuria, edema, renal insufficiency. 4. Gastrointestinal side effects: dyspepsia, heartburn, stomach pain and nausea, acid reflux, etc., which may easily cause gastric ulcer, gastric hemorrhage and perforation. If the above side effects occur during the use of antipyretic suppositories, it is recommended to consult a doctor in a timely manner and take appropriate treatment under the guidance of the doctor.