What medication to take for soreness and weakness in both legs needs to be based on the specific cause of its production. If it is nerve irritation in the lumbar region, resulting in gradual loss of nerve innervation to the muscles of the lower limbs, and soreness and weakness, treatment is needed according to the condition of the lumbar region. If it is lumbar disc herniation, anti-inflammatory and pain relief, dehydration and anti-inflammatory, blood circulation and nerve nutrition medication, such as loxoprofen sodium, diclofenac sodium, methylcobalamin tablets, blood circulation and pain relief capsules, mannitol and dexamethasone injection, can be used to good effect. If it is due to muscle lesions in the leg, such as strain, strain injury, sterile inflammatory lesions, you can take oral Eperisone hydrochloride tablets to relieve muscle tension; oral Nimesulide and Ibuprofen to reduce pain; oral Chinese medicine to activate blood circulation and eliminate blood stasis, reduce swelling and pain, such as Da Qi Li capsule to increase blood circulation and promote the absorption of inflammatory metabolites, can also play a good therapeutic effect. If the problem is due to blood vessels, resulting in poor blood circulation, accumulation of inflammatory metabolites and decreased blood supply, there will also be soreness and weakness. It is best to first conduct an ultrasound examination of the blood vessels of the lower extremities to see the condition of the specific vessels, and this condition is generally not treated with medication first, and should be treated surgically by interventional means.