How long one can live after splenectomy is not easy to generalize, it mainly depends on the original disease, and in most cases, it does not have significant impact on the normal life expectancy. 1. Clinical splenectomy surgery treats most splenic ruptures caused by trauma. As long as there are no serious complications, high platelets can take aspirin and other antiplatelet drugs, to keep not excessively exposed to dangerous environments, splenectomy is basically not a serious danger to survival, and will not have a significant impact on normal life expectancy. 2. Hepatitis, cirrhosis and other causes of splenic blood reflux obstruction, secondary splenomegaly, hypersplenism, portal hypertension, gastric fundus esophageal peripheral varicose veins, usually need splenectomy, portal-splenic vein disconnection. The survival time after splenectomy mainly depends on the degree of cirrhosis and the degree of hepatic decompensation. 3. For splenectomy due to abdominal malignant tumors (e.g. lymphoma) and other reasons, how long one can live after the operation mainly depends on the condition factors of the malignant tumors. Some people need to pay attention to the decline of immunity after splenectomy and are prone to combined bacterial or viral infections, etc. They should consult their physicians for timely management.