Low white blood cells and platelets may be caused by some drugs, or may be caused by some diseases, such as aplastic anemia, leukemia, primary myelofibrosis, etc., should consult the doctor in time to find out the cause of the disease. 1. Drug factors: some anti-viral, anti-inflammatory and analgesic drugs, such as ganciclovir, ibuprofen, etc., as well as patients with malignant tumors after chemotherapy, due to the toxic side effects of chemotherapeutic drugs, such as carboplatin, etc., can cause a decrease in the number of white blood cells and platelets. 2. Disease factors (1) Aplastic anemia: Aplastic anemia is a bone marrow hematopoietic failure disorder caused by different etiologies and mechanisms. When patients check the blood routine, it can suggest that the levels of red and white blood cells and platelets are all reduced, and the clinical symptoms mainly manifest as anemia, bleeding, infection syndrome, and so on. (2) Leukemia: Leukemia is caused by abnormal self-proliferation, differentiation and apoptosis of leukemia cells, which inhibits normal hematopoiesis and infiltrates other organs and tissues, thus causing different degrees of anemia, bleeding, infection, bone pain, and enlarged liver and lymph nodes. Patients with leukemia usually have significantly lower white blood cells and platelets. (3) Primary myelofibrosis: This is a disease characterized by early platelet elevation and late leukocyte and platelet reduction, and patients may have symptoms such as fatigue, night sweats, weight loss, bone pain and anemia. Patients who find leukocyte and platelet reduction in routine physical examination need to go to the hospital in time to improve the relevant examination to clarify the condition, and individualized treatment will be carried out by the doctor according to the diagnosis of the cause of the patient’s disease.