Creatinine 120μmol/L is more serious if it is caused by pathological reasons such as gastrointestinal bleeding and chronic nephritis, and needs targeted treatment for specific causes; if it is caused by physiological factors such as strenuous exercise and eating a large amount of meat, it is generally not serious and can be treated by taking rest and eating a light diet. The normal range of blood creatinine is 53-106 μmol/L for men and 44-97 μmol/L for women, and a blood creatinine of 120 μmol/L indicates possible kidney damage. Common causes such as gastrointestinal bleeding, chronic nephritis, urinary tract obstruction, drug damage, diabetic nephropathy, polycystic kidney, etc., need to clarify the cause of the disease for targeted treatment. Without timely intervention and treatment, the condition may be aggravated, and in severe cases, it will continue to develop into kidney failure, which seriously endangers the patient’s life and requires timely medical treatment. Blood creatinine is produced by human muscle and its metabolism is mainly through glomerular filtration. Physiological factors such as strenuous exercise, eating a lot of meat, muscular athletes, etc., can appear in the blood creatinine elevation, at this time generally do not need special treatment, pay attention to rest, regular review can be. Patients with elevated blood creatinine are advised to consult a doctor in time and not to take medication privately to avoid delaying their condition.