Chronic fatigue syndrome is generally referred to as fatigue syndrome, the cause of which is unclear. Most patients experience symptoms such as decreased mobility and poor sleep quality. The disease is somewhat self-limiting and requires no specific treatment. The cause of fatigue syndrome is still unclear, but it is considered to be related to viral infections, impaired immune system, and disorders of the neuroendocrine system, etc., while aging and stressful life are among the predisposing factors. Usually, the patient’s fatigue tends to be aggravated by exercise or mental activities, and cannot be improved after rest. Typical symptoms include decreased mobility and poor sleep quality. Some patients also suffer from memory loss, headache, night sweats, shortness of breath and other symptoms, which affect their quality of life and health. Since fatigue syndrome is a self-limiting disease, most patients do not require special treatment. However, for some patients with more serious conditions, cognitive behavioral therapy and graded exercises may be prescribed. It is recommended that people with fatigue syndrome rest, listen to music and communicate with others to relieve stress. They should also ensure a balanced intake of nutrients and change their bad habits. If the daily life is seriously affected, it is recommended to consult a doctor as soon as possible, and standardized treatment under the guidance of a professional physician.