The severe pain in dialysis patients every night may be related to hypocalcemia caused by uremia, secondary hyperparathyroidism, neuropathy and other factors; if the pain symptoms are more serious, it is recommended to consult a doctor as soon as possible for clear diagnosis and treatment. 1. Hypocalcemia: Electrolyte metabolism disorder may occur in the late stage of dialysis, causing hypocalcemia, which may lead to osteoporosis and generalized pain, and the pain mostly occurs in bones and joints. 2. Secondary hyperparathyroidism: patients in the late stage of dialysis are often accompanied by excessive secretion of parathyroid hormone, resulting in endocrine disorders, which may cause bone and joint pain, osteoporosis, and vascular metastatic calcification, which may cause generalized pain symptoms. 3. Neuropathy: in the late stage of dialysis, multiple neuropathy may occur, causing generalized pain, accompanied by numbness, muscle weakness and other symptoms. Dialysis patients are recommended to consult regular hospitals for any discomfort and standardized treatment under the guidance of physicians.