Tongue papillitis is usually not cancerous, in which contour papillitis is easily mistaken for tumor, and lobular papillitis is located in the area of tongue tumor, which needs to be differentiated and diagnosed with tumor, as follows. Tongue papillitis includes filiform papillitis, bacterial papillitis, contour papillitis and lobular papillitis, filiform papillitis mainly manifests as atrophic damage of filiform papillae, while other papillitis mainly manifests as congestion, redness, swelling and pain. It is usually not cancerous. When the contour papillae are inflamed, the papillae are enlarged and protruding, which can be easily mistaken for tumors, and the lobed papillae are located at the back of the bilateral tongue margins, which is a good site for tongue tumors. Both of them need to be distinguished from tumors, and for those who have a history of potentially malignant diseases or long-term chronic adverse stimulation, or those who are accompanied by ulcers and pain, local hardness, and do not heal for a long period of time, it is necessary to have histopathological examination for a clear diagnosis. It is recommended to visit the hospital for professional treatment.