Topical gynecological drugs generally do not affect the H. pylori test, the specific medication as prescribed by the doctor. Commonly used Helicobacter pylori tests include breath test, which requires 2 to 3 hours of dietary abstinence before the test, and no history of taking acid-suppressing drugs in the last 2 weeks, and no history of taking bismuth, antibiotics and other drugs in the last 4 weeks, such as omeprazole, bismuth potassium citrate, amoxicillin and so on, so as not to interfere with the test value by food and drugs. And gynecological topical drugs may include antibiotics, but taking into account the local use, generally does not have a great impact on the whole body, so the recent use of topical gynecological drugs generally will not affect the H. pylori test, the specific use of the drug in question should be under the guidance of specialists, and those who have a positive test for H. pylori should be treated in a timely manner.