The difference between Zuo Gui Wan and Liu Wei Di Huang Wan mainly lies in the composition of the drugs and the different focuses of efficacy, Zuo Gui Wan is tonic without diarrhea, nourishing the kidneys and tonifying the yin, while Liu Wei Di Huang Wan is a combination of diarrhea and tonic, filling the essence and tonifying the kidneys. 1. Zuo Gui Wan: composed of ripe earth, yam, wolfberry, dogwood, hyssop, cuscuta, deer glue, turtle glue. In this formula, Radix Rehmanniae Praeparata nourishes kidney yin; Fructus Lycii nourishes kidney essence, nourishes liver and eyesight; Colla Cornu Cervi Pantotrichum nourishes kidney essence; Cornus Cornu Cervi Pantotrichum nourishes liver and kidney, astringes essence and stops spermatorrhea (consolidates essence and prevents spermatorrhea); Chinese yam nourishes spleen and benefits the kidneys; Achyranthes Bidentata benefits the kidney and the liver and strengthens waist and knees. The whole formula nourishes the kidney and replenishes the yin, and is used in treating deficiency of true yin and kidney water. 2. Six-flavored Dihuang Pill: composed of Radix Rehmanniae Praeparata, Rhizoma Dioscoreae, Rhizoma Dioscoreae, Cornu Cervi Pantotrichum, Poria, Zedoariae, and Mudan Pi. In the formula, Radix Rehmanniae Praeparata nourishes kidney yin; Cornu Cervi Pantotrichum nourishes liver and kidney; Radix Rehmanniae Praeparata nourishes spleen yin; Ze Xie Di diarrhea nourishes dampness and strengthens the spleen; Radix et Rhizoma Mudanensis diarrhealizes the phase fire; Poria lubricates dampness. The dosage of tonic is heavier than that of laxative, with tonic as the mainstay and laxative as a supplement. It is used for treating soreness and weakness of waist and knees (a feeling of soreness and weakness of waist and knees), bone vaporization and tidal heat (a burst of heat, feeling that the heat is penetrating from inside the bones to the outside) caused by deficiency of kidney yin. Zuo Gui Wan is a tonic without diarrhea, and is used to treat deficiency of genuine yin; Liu Wei Di Huang Wan is a tonic with diarrhea, and is used to treat deficiency of kidney yin and internal heat, and should be prescribed by a Chinese medicine practitioner for the purpose of diagnosis.