There are more causes of acute upper gastrointestinal bleeding, mainly as follows: 1, upper gastrointestinal tract diseases: including esophagitis with erosion, esophageal cancer, cardia mucosa tearing syndrome and other esophageal diseases, peptic ulcer, acute gastritis, gastric cancer and other gastric and duodenal diseases; 2, rupture and bleeding of esophagogastric fundic varices caused by portal hypertension: portal vein is a pathway to collect blood from various organs into the liver. When lesions occur in the destination, such as liver cirrhosis, and portal vein obstruction caused by portal phlebitis, portal vein thrombosis and other diseases, will lead to the smooth flow of blood to the organs of the digestive tract, varices occur, and finally rupture and bleeding; 3, lesions in the adjacent organs or tissues of the upper gastrointestinal tract: such as aneurysm rupture into the digestive tract, mediastinal tumor or abscess breaking into the esophagus; 4, biliary tract diseases: such as biliary ascariasis, gallbladder or bile duct stones, gallbladder or bile duct cancer, etc.; 5, blood diseases: such as leukemia, hemophilia, aplastic anemia can lead to coagulation dysfunction and increase the probability of bleeding; 6, other: burns, severe trauma or stress ulcers occurring after major surgery can cause acute upper gastrointestinal bleeding.