The difference between cholangiocarcinoma and jugular carcinoma is manifested in the aspects of site of onset, symptoms and so on. 1. Incident site: ① Cholangiocarcinoma refers to malignant tumors occurring in epithelial cells of bile ducts, which can be divided into intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma. Jugular carcinoma refers to malignant tumors that appear around the main pancreatic duct at the head of pancreas close to the duodenal papilla and converge with the common bile duct to form an enlarged Vater jugular abdomen. 2. Symptoms: ① Early stage of cholangiocarcinoma usually has no symptoms, or the symptoms are relatively mild, and it is found in middle or late stage. Typical symptoms include jaundice, enlarged gallbladder, liver size, biliary tract infection and loss of appetite. ② Typical symptoms of jugular carcinoma are painless progressive jaundice, and symptoms such as loss of appetite and gastrointestinal bleeding may also occur. If jaundice and other discomforts occur, go to regular hospitals for timely consultation, confirm the diagnosis of the disease and standardize the treatment.