Escitalopram and mirtazapine can be taken together, there is no contraindication, there is no evidence-based evidence that the same use will have adverse conflicts, can be used jointly for the treatment of depression, but need to have a physician’s guidance, to be based on the patient’s condition to formulate a specific plan of medication. 1. escitalopram commonly used dosage form has tablets, used for the treatment of treatment of panic disorder with or without square phobia as well as depressive disorders. Adverse effects are commonly associated with decreased libido, increased or decreased appetite, weight gain, insomnia or drowsiness, constipation or diarrhea, dry mouth, vomiting, increased sweating, joint pain, and fatigue. Contraindications are prohibited for those who are allergic to it; prohibited to be combined with pimozide; prohibited to be combined with linezolid. Note that there is usually a discontinuation reaction when treatment is stopped; use with caution in patients with a history of bleeding disorders. 2. Mirtazapine is available in orally disintegrating tablets and tablets for the treatment of depression. The common adverse effects of this product include weight gain, increased appetite, headache, drowsiness, dry mouth, fatigue, vomiting, diarrhea, anxiety, and insomnia. Contraindicated is hypersensitivity to the product. Note that the medication should be used from the minimum amount to avoid overdose. Escitalopram and mirtazapine should be applied under the guidance of a physician, do not self-medicate to avoid causing adverse reactions.