Hiccups in children means increased accumulation of gas in the upper gastrointestinal tract and stomach, and chest pain in conjunction with hiccups in children should be analyzed by considering that the child has a chronic upper gastrointestinal tract disease, such as chronic gastritis, gastric ulcer, duodenitis, duodenal ulcer, reflux gastroesophagitis, and so on. Gastric contents can reflux and affect the esophagus, causing damage to the esophageal mucosa and chest pain. At this point, the child should be taken to a pediatric gastroenterology clinic, where pediatric gastroscopy may be necessary, as well as testing for Helicobacter pylori, which is the most common pathogenetic cause of the above conditions. Once the diagnosis is established, anti-H. pylori testing and treatment needs to be standardized, usually with two of the three antibiotics amoxicillin, clarithromycin, or metronidazole, combined with a proton pump inhibitor for anti-H. pylori therapy. Symptomatic supportive therapy such as gastric protection is also needed, as well as good dietary management to avoid irritating foods.