Low cortisol can be seen in primary hypoadrenocorticism, secondary hypoadrenocorticism and other diseases, depending on the causes of low cortisol need to take different treatment programs, including drug treatment, surgical treatment and so on. It is recommended to follow the doctor’s instructions. 1. Primary hypoadrenocorticism: A basal amount can be determined according to the patient’s height, age, weight, gender and other factors, and hydrocortisone supplementation can be used for treatment. Salt corticosteroids may also be supplemented. If the primary hypoadrenocorticism is caused by tuberculosis, anti-tuberculosis treatment with isoniazid and rifampicin is also needed. 2. Secondary hypoadrenocorticism: Pituitary or hypothalamic lesions can cause secondary hypoadrenocorticism. If it is caused by tumor, surgical resection should be considered, and hormone replacement therapy, such as hydrocortisone, can also be used. It is recommended to go to the hospital when low cortisol occurs, and ask the doctor to make a judgment and clarify the cause of the disease.