The disappearance of aortic pulse wave is a manifestation of atherosclerosis, which requires prompt vasoprotective and thrombolytic treatment. Atherosclerosis leads to a significant narrowing of the local lumen of the blood vessels, resulting in impaired blood circulation. Prolonged circulatory disorders will cause different degrees of cardiac function damage and weakening of ventricular wall motion, which will lead to the disappearance of aortic pulse waves on the electrocardiogram (ECG). However, in addition to the ECG results, a number of ancillary tests such as arteriograms and X-rays are needed to confirm the diagnosis of atherosclerosis. After the symptoms of atherosclerosis or loss of aortic pulse, it is recommended to go to the hospital as soon as possible for echocardiography or coronary CT angiography to determine the exact location of the atherosclerosis, so as to choose the appropriate thrombolytic or interventional program for arterial treatment. Early control of atherosclerosis can effectively protect cardiovascular health, so early treatment is recommended after an abnormal ECG or a clear diagnosis.