In general, cimetidine and aluminum sulfate taken together will reduce the effect of cimetidine to inhibit gastric acid, and will also affect the efficacy of aluminum sulfate to protect gastric mucosa. Therefore, it is not recommended to take them at the same time.
1. The effect of cimetidine: cimetidine is an Hâ‚‚ receptor blocker, belonging to the inhibition of gastric acid secretion, is currently one of the first choice of drugs for the treatment of peptic ulcer. Cimetidine enters the stomach through oral intake and is absorbed by the blood vessels in the stomach so as to play a role. Taken together with aluminum sulfate, it will affect the absorption of cimetidine by the gastric mucosa because aluminum sulfate covers the gastric mucosa, thus reducing the efficacy of the drug.
2. Effect on aluminum thiosulfate: aluminum thiosulfate is a kind of gastric mucous membrane protection agent, which needs to be hydrolyzed by gastric acid to be effective. Taking with cimetidine will reduce the secretion of gastric acid due to the inhibition of gastric acid by cimetidine, which will reduce the hydrolysis of aluminum thiosulfate in the stomach and affect the efficacy of the drug.
In addition, both cimetidine and aluminum thiosulfate should be taken under the guidance of a doctor, and should not be used without authorization.