Malignant melanoma is a highly malignant tumor derived from melanocytes. It is insidious, highly malignant, has a poor prognosis, and is clinically rare, accounting for about 1% of all skin malignancies. Malignant melanoma can be seen at any age, more often in middle age and old age, and slightly more often in women than men. The disease occurs mostly in white people, especially those with a history of sun exposure, and has a high incidence in the United States and Australia, while the incidence in China is low. Cutaneous melanoma can occur in any part of the skin and is most often seen in fair or shiny skin, especially in people with a history of sun exposure. Closely related to pigment-containing lesions, the possibility of early cutaneous malignant melanoma is often suggested when lesions show the following changes: 1. color changes, especially blue-black, gray, brown, and miscellaneous colors are most important; 2. irregular surface elevation, roughness, desquamation, and oozing; 3. jagged and jagged periphery; 4. rapid increase in lesion size, persistent itching, crusting, or appearance of satellite nodules. The lesions of melanoma are difficult to heal after friction or injury, and ulcers may be formed. Dark bloody exudate may flow from the ulcers, and there may be pigmentation in the surrounding skin, and regional lymph node enlargement may appear. The number of common colored nevi is also related to the development of melanoma, but about 10% of melanomas do not produce melanin and are called anaplastic melanoma. In addition to the above common clinical manifestations, the diagnosis of malignant melanoma is mainly based on pathological diagnosis. For lesions suspected of melanoma, excisional biopsy is recommended, avoiding needle aspiration, biting or excisional biopsy, and once diagnosed, early radical surgery is recommended.