Symptoms of large osteoarthrosis include the following stages: First, early joint mild pain, inconvenient movement, morning stiffness, and frictional sensation in the joints. Second, the middle stage of the disease has increased pain, enlarged joints, short and thick fingers and toes, restricted movement, muscle atrophy, and joint free bodies. Third, in the late stage of the disease, short stature, short and thick fingers, thick joints, muscle atrophy is more obvious, the onset of talus pain is obvious, and in severe cases, the joints of the limbs and the spine are seriously deformed. Large osteoarthrosis is prevalent in the northeast of China, due to the long-term use of Fusarium contaminated cereals and drinking water containing too much strontium, iron and barium, while calcium and magnesium are too low, and the lesions first invade the epiphyseal plate, causing destruction and calcification of the epiphyseal plate and early fusion of the epiphysis with the backbone.