Gene fusion-associated kidney cancer is caused by gene fusion due to gene breakage, which is mostly found during physical examination and should be treated by surgery as early as possible. Gene fusion-associated renal cancer is caused by gene translocation and breakage, resulting in the formation of a new fusion gene, which leads to tumor formation. Most of the gene fusion-associated tumors are found during physical examination, and as the disease progresses, symptoms such as hematuria, lumbar and abdominal pain, abdominal mass and so on may appear. If gene fusion-associated renal cancer is suspected, one can go to regular hospitals for genetic testing and renal enhancement CT to confirm the diagnosis. Surgery is the first choice of treatment, and radical nephrectomy can be performed on patients with limited gene fusion-associated renal cancer according to the doctor’s advice to get the best prognosis, and partial nephrectomy can be considered for limited tumors with a diameter of less than 4 cm. If distant metastasis occurs, targeted drug therapy can be considered. It is recommended that patients go to regular hospitals in time to avoid the deterioration of the condition.